Potent inhibitors of the MAP kinase p38

J R Henry; K C Rupert; J H Dodd; I J Turchi; S A Wadsworth; D E Cavender; P H Schafer; J J Siekierka

doi:10.1016/s0960-894x(98)00589-7

Potent inhibitors of the MAP kinase p38

Bioorg Med Chem Lett. 1998 Dec 1;8(23):3335-40. doi: 10.1016/s0960-894x(98)00589-7.

Authors

J R Henry¹, K C Rupert, J H Dodd, I J Turchi, S A Wadsworth, D E Cavender, P H Schafer, J J Siekierka

Affiliation

¹ R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.

PMID: 9873730
DOI: 10.1016/s0960-894x(98)00589-7

Abstract

The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-alpha and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

MeSH terms

Anti-Inflammatory Agents / chemical synthesis*
Anti-Inflammatory Agents / pharmacology
Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors*
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology
Humans
Imidazoles / pharmacology
Intracellular Signaling Peptides and Proteins
Lipopolysaccharides / pharmacology
Mitogen-Activated Protein Kinases*
Protein Serine-Threonine Kinases / antagonists & inhibitors
Pyridines / pharmacology
Tumor Necrosis Factor-alpha / antagonists & inhibitors
p38 Mitogen-Activated Protein Kinases

Substances

Anti-Inflammatory Agents
Enzyme Inhibitors
Imidazoles
Intracellular Signaling Peptides and Proteins
Lipopolysaccharides
Pyridines
Tumor Necrosis Factor-alpha
MAP-kinase-activated kinase 2
Protein Serine-Threonine Kinases
Calcium-Calmodulin-Dependent Protein Kinases
Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases
SB 203580